white blood cell from cells at work

The different types of white blood cells (leukocytes) include neutrophils, immune system functions take more time to initiate, but work much faster. GIANTmicrobes and Cells at Work! have collaborated to bring you this special collection of your favorite characters! These soft plush cells are adorable and. Cells at Work is a Japanese manga series written and illustrated by Akane Shimizu. The series largely focuses on two such cells; a rookie red blood cell.

: White blood cell from cells at work

White blood cell from cells at work
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The second instalment of Cells At Work continues to follow the experiences of Red Blood Cell AE3803 (Kana Hanazawa) and White Blood Cell U-1146 (Tomoaki Maeno), as they travel around the body. (Screenshot: Netflix)

Cast: Kana Hanazawa, Tomoaki Maeno, Daisuke Ono
Language: Japanese with various subtitles

Streaming on Netflix from 30 July

This review covers all episodes of Cells At Work Season 2.

SINGAPORE — An unorthodox anime, Cells At Work personifies the cells of a human body, illustrating their functions as if they are employees in a big company. The second season continues to follow the experiences of Red Blood Cell AE3803 (Kana Hanazawa), who is no longer a rookie, and White Blood Cell U-1146 (Tomoaki Maeno), as they travel around the body. (You can also read our review of the spin-off series, Cells At Work: Code Black, here.)

While the first season focuses on the relatively more common cells, such as the different kinds of white blood cells including the aggressive Killer T Cell (Daisuke Ono) and the lovely yet violent Macrophage, and the cute Platelets, the second season dives in deeper to the less known cells (at least for someone with minimal biology knowledge), such as the Megakaryocyte that produces platelets, the Mast Cell that releases histamine, and the Dendritic Cell that produces cytokines used in cell signalling.

Cells At Work may be a biology anime, but it should be noted that the story has greatly simplified the functions of trillions of cells that exist in a human body. Along with its comedic elements, the anime is an enjoyable introduction to the multi-faceted human biology, which helps people understand what’s going on in their bodies a little better.

Unlike the first season that hardly talks about external support like medicines — it mainly covers how the body reacts to threats – the second season is more well-rounded with topics on acquired immunity through vaccination (how relevant during this pandemic situation!) and the benefits of ingesting lactic acid bacteria.

What makes Cells At Average american savings 2020 more like a regular anime and less dry like a school subject is how it pits the human body's cells as the protagonists against the bacteria and viruses as the antagonists. In fact, there is even a nemesis — the Cancer Cell, hell-bent on creating a world where cells no longer have to kill each other, even if it means risking the life of the body. The Cancer Cell first appeared in episode seven of the first season, and later gets a revival in the finale of the second season.

Although the first season tends to explore one topic per episode, usually with a new cell introduced, the second season plays it differently with some episodes having two topics. Although Season 2 only has a short eight episodes, as compared to the 13 episodes in the first season, the content is still as rich and interesting.

If you’d like to learn about the human body's cells in a more engaging and fun manner, Cells At Work is a good place to start. After finishing the second season, you may understand the importance and benefits of vaccination, especially in light of the coronavirus, and may even look into consuming more lactic acid bacteria.

Get more TV and movie news from Yahoo Lifestyle on our Entertainment page.

Источник: https://news.yahoo.com/cells-at-work-season-2-review-benefits-of-vaccination-probiotics-explained-080518921.html

Cells at Work!

Japanese manga series

A woman in red holds a package, standing next to a man clad in white clothes with bloodstains

The cover of the first volume of Cells at Work!, featuring Red Blood Cell AE3803 and White Blood Cell U-1146

Written byAkane Shimizu
Published byKodansha
English publisher
MagazineMonthly Shōnen Sirius
Original runJanuary 26, 2015 – January 26, 2021
Volumes6 (List of volumes)
Illustrated byHaruyuki Yoshida
Published byKodansha
English publisher
Original runMay 2017 – August 2020
Volumes7 (List of volumes)
Illustrated byMoe Sugimoto
Published byKodansha
English publisher
MagazineMonthly Shōnen Sirius
Original runJuly 26, 2017 – present
Volumes4 (List of volumes)
Directed by
  • Kenichi Suzuki (season 1)
  • Hirofumi Ogura (season 2)
Produced byYuma Takahashi
Written by
  • Yūko Kakihara
  • Kenichi Suzuki
Music by
StudioDavid Production
Licensed by
Original networkTokyo MX, GYT, ytv, BS11, MBS, TV Aichi, HBC, RKB
English network
Original run July 8, 2018 – February 27, 2021
Episodes21 + Special (List of episodes)
Written byYui Tokiumi
Illustrated byAkane Shimizu
Published byKodansha
PublishedJuly 12, 2018
Written byKanna Kurono
Illustrated byMio Izumi
Published byKodansha
English publisher
MagazineBessatsu Friend
Original runJanuary 12, 2019 – present
Volumes5 (List of volumes)
Written byYuuko Kakihara
Illustrated byYasu
Published byKodansha
English publisher
MagazineMonthly Shōnen Sirius
Original runMay 25, 2019 – present
Volumes3 (List of volumes)
Illustrated byYasuhiro Fukuda
Published byKodansha
English publisher
Original runOctober 17, 2019 – present
Volumes3 (List of volumes)
Written byShigemitsu Harada
Illustrated byAkari Otokawa
Published byKodansha
MagazineMonthly Morning Two
Original runJanuary 22, 2020 – present
Volumes2 (List of volumes)
Directed byHirofumi Ogura
Written byYūko Kakihara
Music by
StudioDavid Production
Licensed by


Muse Communication

ReleasedSeptember 5, 2020 (2020-09-05)
Runtime112 minutes
Written byTetsuji Kanie
Published byKodansha
English publisher
MagazineMonthly Shōnen Sirius
Original runOctober 26, 2020 – present
Volumes1 (List of volumes)
Wikipe-tan face.svg Anime and manga portal

Cells at Work! (Japanese: はたらく細胞, Hepburn: Hataraku Saibō) is a Japanese manga series written and illustrated by Akane Shimizu. It features the anthropomorphized cells of a human body, with the two main protagonists being a red blood cell and a white blood cell she frequently encounters. It was serialized in Kodansha's shōnen manga magazine Monthly Shōnen Sirius from January 2015 to January 2021. It is licensed in North America by Kodansha USA.

An anime television series adaptation by David Production premiered on July 8, 2018, with two seasons and 21 half-hour episodes aired as of February 27, 2021. A theatrical anime titled "Hataraku Saibō!!" Saikyō no Teki, Futatabi. Karada no Naka wa "Chō" Ōsawagi! premiered in September 2020. The anime adaptation of its spin-off series, Cells at Work! Code Black, premiered in January 2021.


The story takes place inside the human body, where trillions of anthropomorphic cells each do their job to keep the body healthy. The series largely focuses on two such cells; a rookie red blood cell, AE3803, who often gets lost during deliveries, and a relentless white blood cell, U-1146, who fights against any germs that invade the body.


Erythrocyte / Red Blood Cell (AE3803) (赤血球, Sekkekkyū)
Voiced by: Kana Hanazawa[3] (Japanese); Cherami Leigh[4] (English)
A red blood cell who has just started her job, delivering oxygen, carbon dioxide and different nutrients all over the body. She meets Neutrophil when he saves her from an attacking pneumococcus bacterium. She is clumsy and gets lost often, but is determined to perform to the best of her ability. It is later revealed that she had encountered Neutrophil when they were younger, after he saved her from a bacterium.
Neutrophil (好中球, Kōchūkyū) / White Blood Cell (U-1146) (白血球, Hakkekkyū)
Voiced by: Tomoaki Maeno[3] (Japanese); Billy Kametz[4] (English)
A type of white blood cell, whose job is to kill pathogens infecting the body. Despite his violent and ruthless occupation, he's quite soft-spoken and gentle. When he was still in school as a young cell, he saved AE3803 from a bacterium after she got lost in a training exercise.
Killer T Cell (キラーT細胞, Kirā Tī Saibō)
Voiced by: Daisuke Ono[3] (Japanese); Robbie Daymond[4] (English)
A type of white blood cell that recognizes and kills various foreign matter and unhealthy cells. He is aggressive, cocky and rowdy, brutally taking pleasure in slaughtering pathogens and unhealthy cells. He especially looks down on white blood cells forming relationships with non-white blood cells, like Neutrophil's close friendship with Red Blood Cell. He is the sergeant of the Killer T Cells and is a harsh teacher to his students, the Naive T Cells. He has negative relationships with Helper T Cell and NK Cell, the former being his superior in the Killer T Division. In his youth, he was considered to be weak like the rest of the young T Cells, being only able to survive and complete training through the help of Helper T Cell, which at least made him stronger.
Macrophage (マクロファージ, Makurofāji) / Monocyte (単球, Tankyū)
Voiced by: Kikuko Inoue[3] (Japanese); Laura Post[4] (English)
A type of white blood cell. She and her kind appear as lovely maids in big dresses, armed with a variety of large weapons to fight various white blood cell from cells at work pathogens, and are often shown smiling cheerfully even in the middle of combat. While inside blood vessels, she and her kind take on the role of monocytes, and wear hazmat suits over their dresses.
Platelet (血小板, Kesshōban)
Voiced by: Maria Naganawa[3] (Japanese); Xanthe Huynh[4] (English)
A type of cell responsible for reconstructing the body after various injuries. They are depicted as children, due to their small cell size, and act as construction and repair crew within the body. One platelet who carries a whistle on her neck serves as their leader and she is most prominently featured in the show, while a secondary yet shy platelet known as "Backward Cap" because she wears her cap backwards, also appears in the story.
Helper T Cell (ヘルパーT細胞, Herupā Tī Saibō)
Voiced by: Takahiro Sakurai[5] (Japanese); Ray Chase[4] (English)
A type of T Cell that white blood cell from cells at work strategy and courses of action for dealing with foreign invaders. He is the main commander of the Killer T Division and has an intellectual and smooth disposition, putting him at big odds with the rough and tough Killer T Cell, despite having undergone T Cell training together with him.
Regulatory T Cell (制御性T細胞, Seigyosei Tī Saibō)
Voiced by: Saori Hayami[5] (Japanese); Erica Mendez[4] (English)
A type of T Cell that mediates and regulates the correct function and magnitude of immunological captain america civil war imdb. She usually acts as Helper T Cell's secretary, though she is capable of fighting when necessary. She went through T Cell training alongside Killer T Cell and Helper T Cell.
Naive T Cell (ナイーブT細胞, Naību T Saibō)
Voiced by: Mutsumi Tamura (Japanese); Laura Stahl[6] (English)
A rookie T Cell who is too frightened to fight invasive microorganisms, until Dendritic Cell helps him transform into Effector T Cell. He and his kind are the students of Killer T Cell, from whom they receive harsh treatment and austere training.
Effector T Cell (エフェクターT細胞, Efekutā T Saibō)
Voiced by: Kenji Nomura (Japanese); Chris Tergliaferra[6] (English)
A Naive T Cell transformed into a large, muscular and powerful T Cell.
Eosinophil (好酸球, Kōsankyū)
Voiced by: M.A.O[5] (Japanese); Kayli Mills[4] (English)
A type of white blood cell who is acquainted with White Blood Cell since they grew up in the same bone marrow. She feels inferior to the other immune cells because of her inability to fight off bacteria and viruses, but she shows her true worth by killing a parasitic Anisakis when the other cells could not. She handles a bident as her weapon of choice.
Dendritic Cell (樹状細胞, Jujō Saibō)
Voiced by: Nobuhiko Okamoto[5] (Japanese); Griffin Burns[4] (English)
Depicted as a messenger dressed in green stationed inside a call center resembling a tree. He can stimulate Naive T Cells and transform them into Effector T Cells. He owns a camera which he always uses to take pictures of events he deems important and stores them in picture albums, some of which are sources of shame and humiliation for the other cells.
Memory Cell (記憶細胞, Kioku Saibō)
Voiced by: Yuichi Nakamura[7] (Japanese); Dave Vincent[6] (English)
A paranoid and neurotic cell whose job is to remember past infections and allergies so that the immunity system can be ready for them. However, he is scatterbrained and it is difficult for him to sort out his memories, often panicking and screaming whenever disaster strikes.
Mast Cell (マスト細胞, Masuto Saibō)
Voiced by: Ayako Kawasumi[7] (Japanese); Maureen Price[6] (English)
A cell whose job is to monitor and release histamines in response to allergic and inflammatory reactions. She always follows the instructions in her book no matter the situations and is unpopular due to her lack of consideration of what her actions do to the other cells. Also known as "Fat Cell", she gets irked whenever she is referred to with that name.
Senior Red Blood Cell (AA5100) (先輩赤血球, Senpai Sekkekkyū)
Voiced by: Aya Endo[7] (Japanese); Kira Buckland[6] (English)
An older red blood cell who sometimes guides and teaches AE3803 on how to properly perform her occupation.
Junior Red Blood Cell (NT4201) (後輩赤血球, Kōhai Sekkekkyū)
Voiced by: Yui Ishikawa (Japanese); Jeannie Tirado (English)
A young but overly serious red blood cell who becomes AE3803's student.
B Cell (B細胞, Bī Saibō)
Voiced by: Shōya Chiba[8] (Japanese); Erik Scott Kimerer[4] (English)
A white blood cell who carries a weapon that shoots antibodies. He is often annoyed and jealous about not receiving as much credit as the Killer T Cells do. He also has an antagonistic relationship with Mast Cell, as their combined functions only cause grave disasters for the other cells.
Basophil (好塩基球, Kōenkikyū)
Voiced by: Tomokazu Sugita (Japanese); D. C. Douglas[6] (English)
A mysterious and poetic character whose real occupation is unknown, appearing during a food-borne infection to make cryptic commentaries on the disastrous events unfolding.
NK Cell (NK細胞, NK Saibō)
Voiced by: Toa Yukinari [ja] (Japanese); Morgan Berry[4] (English)
She patrols the whole body for viruses, bacteria and abnormal cells, with her weapon of choice being a machete. She has a smug demeanor, is somewhat condescending towards other cells and her relationship with Killer T Cell is akin to that of an intense sibling rivalry.
Cancer Cell (がん細胞, Gan Saibō)
Voiced by: Akira Ishida[9] (Japanese); Khoi Dao[6] (English)
An antagonistic cell white blood cell from cells at work on creating a world where cells no longer have to kill each other, even if it means risking the life of the body.[10]
Normal Cell / Cell Boy (正常細胞, Seijō Saibō)
Voiced by: Yūsuke Kobayashi
Normal Cell is a minor character who plays a major role in season 2. Normal Cell is a soft-hearted troublemaker. He finds his job of copying himself boring hence he began to venture outside of his apartment to explore or mess around. Despite not being able to do anything, he has a strong will to protect someone that is precious to him (Lactic Acid Bacteria). According to AE3803, he lives by the pharynx, which happens to be an area that contains lymph nodes.



Cells at Work! is written and illustrated by Akane Shimizu. It was serialized in Kodansha's shōnen manga magazine Monthly Shōnen Ubank customer service hours from January 26, 2015, to January 26, 2021.[11][12][13] Kodansha has collected the manga into five tankōbon volumes as of August 2017[update].[14]

Kodansha USA announced that it had licensed Cells at Work! in North America on March 21, 2016.[15] The manga is also licensed in Taiwan by Tong Li Publishing.[16] Kodansha USA also announced that it has licensed Cells at Work! Code Black.[17]Kodansha USA has also licensed five other spin-offs Cells at Work!: Bacteria!, Cells at Work!: Platelets! and Cells at Work!: Baby!, Cells at Work! Neo Bacteria, and Cells at Work! White Brigade.[18][19]


The manga received a spin-off in the May 2017 issue of Nakayoshi called Cells at Work!: Bacteria! (はたらく細菌; "Bacteria at Work") by Haruyuki Yoshida,[20] which follows the lives of good and bad bacteria in the intestines.[21][22] On June 3, 2020, it was announced that Cells at Work!: Bacteria! would end on July 3, 2020.[23]

Another spin-off, titled Cells NOT at Work! (はたらかない細胞; "Cells That Don't Work") by Moe Sugimoto, about immature red blood cells (erythroblasts) that do not want to work, was launched in the September 2017 issue of Monthly Shōnen Sirius.[24]

The manga received another spin-off titled Cells at Work! Code Black (はたらく細胞BLACK), set in a "black" environment of a human body suffering an unhealthy lifestyle, that runs in Weekly Morning since June 7, 2018. It is written by Shigemitsu Harada, with illustrations by Issei Hatsuyoshi and supervision by Shimizu.[25]

The manga received another spin-off titled Cells at Work and Friends! (はたらく細胞フレンド; "Cells at Work! Friend"), which centers around a Killer T Cell who is normally strict with himself and others, but wants to have fun during his free time. He also wants to susquehanna community bank locations friends but does not want to ruin his reputation. The series began running in Bessatsu Friend on January 12, 2019. It is written by Kanna Kurono, and illustrated by Mio Izumi.[26]

Another spin-off series focusing on the platelet characters, titled Cells at Work!: Platelets! (はたらく血小板ちゃん, Platelets at Work) written by Kanna Kurono and illustrated by Mio Izumi, began serialization in the June issue of Monthly Shōnen Sirius that was released on May 25, 2019.[27]

Another spin-off series focusing cells inside the body of a baby 40 weeks since conception and nearing delivery, with the cells knowing nothing, titled Cells at Work!: Baby! (はたらく細胞BABY) illustrated by Yasuhiro Fukuda, was launched in the 45th issue of Weekly Morning on October 17, 2019.[28]

Another spin-off series focusing on cells in the body of an adult woman, titled Cells at Work!: Lady! (はたらく細胞LADY) written by Harada and illustrated by Akari Otokawa, was launched in the March issue of Monthly Morning Two on January 22, 2020.[29]

Another spin-off series focusing on white blood cells, titled Cells at Work!: WHITE (はたらく細胞WHITE) illustrated by Tetsuji Kanie, was launched in the December issue of Monthly Shōnen Sirius, which was released in October 2020.[30]

Volume list[edit]

Cells at Work![edit]
No.Original release date Original ISBN North America release date North America ISBN
1 July 9, 2015[31]978-4-06-376560-1November 1, 2016[32]978-1-63236-356-5
  • 1. "Pneumococcus" (肺炎球菌, Haienkyūkin)
  • 2. "Cedar Pollen Allergy" (スギ花粉アレルギー, Sugi Kafun Arerugī)
  • 3. "Influenza" (インフルエンザ, Infuruenza)
  • 4. "Scrape Wound" (すり傷, Surikizu)
2 November 20, 2015[33]978-4-06-376589-2December 27, 2016[34]978-1-63236-357-2
  • 5. "Food Poisoning" (食中毒, Shokuchūdoku)
  • 6. "Heat Stress" (熱中症, Netchūshō)
  • 7. "Erythroblasts and Myelocytes" (赤芽球と骨髄球, Sekigakyū to Kotsuzuikyū)
  • 8. "Cancer Cells (Part I)" (がん細胞(前編), Gan Saibō (Zenpen))
  • 9. "Cancer Cells (Part II)" (がん細胞(後編), Gan Saibō (Kōhen))
3 June 9, 2016[35]978-4-06-390633-2March 28, 2017[36]978-1-63236-390-9
  • 10. "The Circulatory System" (血液循環, Ketsueki Junkan)
  • 11. "The Common Cold" (風邪症候群, Kaze Shōkōgun)
  • 12. "Thymocytes" (胸腺細胞, Kyōsen Saibō)
  • 13. "Acquired Immunity" (獲得免疫, Kakutoku Men'eki)
  • 14. "Acne" (ニキビ, Nikibi)
4 November 30, 2016[37]978-4-06-390664-6May 2, 2017[38]978-1-63236-391-6
  • 15. "Staphylococcus aureus" (黄色ブドウ球菌, Ōshoku Budō Kyūkin)
  • 16. "Dengue Fever" (デング熱, Dengu Netsu)
  • 17. "Hypovolemic Shock (Part I)" (出血性ショック(前編), Shukketsusei Shokku (Zenpen))
  • 18. "Hypovolemic Shock (Part II)" (出血性ショック(後編), Shukketsusei Shokku (Kōhen))
  • 19. "Peyer's Patch" (パイエル板, Paieru-ban)
5 August 9, 2017[39]978-4-06-390720-9November 21, 2017[40]978-1-63236-426-5
  • 20. "H. Pylori" (ピロリ菌, Pirorikin)
  • 21. "Antigenic Shift" (抗原変異, Kōgen Hen'i)
  • 22. "Cytokines" (サイトカイン, Saitokain)
  • 23. "Harmful Bacteria" (悪玉菌, Akudamakin)
  • 24. "Cancer Cell II (Part I)" (がん細胞2(前編), Gan Saibō Tsū (Zenpen))
  • 25. "Cancer Cell II (Part II)" (がん細胞2(後編), Gan Saibō Tsū (Kōhen))
6 February 9, 2021[14]978-4-06-522252-2June 22, 2021[41]978-1-63236-427-2
  • 26. "Bump" (でこぼこ, Dekoboko)
  • 27. "Move to the Left" (左方移動, Hidari ni Idō)
  • 28. "IPS Cells" (ips細胞, Ips Saibō)
  • 29. "New Coronavirus (Part I)" (新型コロナウイルス(前編), Shingata Koronauirusu (Zenpen))
  • 30. "New Coronavirus (Part II)" (新型コロナウイルス(後編), Shingata Koronauirusu (Kōhen))
  • Special- "Psoriasis Edition" (乾癬, Kansen)
Cells at Work!: Bacteria![edit]
Cells NOT at Work![edit]
Cells at Work and Friends![edit]
Cells at Work!: Platelets![edit]
Cells at Work!: Baby![edit]
Cells at Work!: Lady![edit]
Cells at Work!: White Brigade[edit]
Cells at Work!: Neo Bacteria![edit]


An anime television series adaptation was announced in January 2018. It is directed by Kenichi Suzuki and animated by David Production, with scripts written by Suzuki and Yūko Kakihara, and character designs by Takahiko Yoshida. The series' music is composed by Kenichiro Suehiro and MAYUKO. The anime series premiered on July 8, 2018, on Tokyo MX and other channels.[7][68][69] The series ran for 13 episodes.[70]Aniplex of America licensed home remedies for migraines during pregnancy series in North America and simulcast it on Crunchyroll.[71]Madman Entertainment simulcasted Australia and New Zealand on AnimeLab,[72] while Muse Communication licensed the series in Southeast Asia and South Asia, and simulcasted it on Animax Asia.[73]MVM Entertainment acquired the series for distribution in the United Kingdom and Ireland.[74] The opening theme is "Mission! Health Comes First" (ミッション! 健・康・第・イチ, Mission! Ken - Kō - Dai - Ichi) by Kana Hanazawa, Tomoaki Maeno, Daisuke Ono, and Kikuko Inoue in Japanese and Cherami Leigh, Billy Kametz, Robbie Daymond and Laura Post in English,[7][75] while the ending theme is "CheerS" by ClariS.[76] A special episode premiered on December 27, 2018.[77] Aniplex of America released the English dub on August 27, 2019.[4]

On March 23, 2019, the official Twitter account announced that the series will receive a second season.[78] The second season aired from January 9 to February 27, 2021.[79] The main staff at David Production is returning for producing the second season, with the exception of director Kenichi Suzuki being replaced by director Hirofumi Ogura. The opening theme is "Go! Go! Saibō Festa!" by the main cast members, while the ending theme is "Fight!!" by ClariS.[80]

A theatrical anime titled "Hataraku Saibō!!" Saikyō no Teki, Futatabi. Karada no Naka wa "Chō" Ōsawagi! was announced on July 4, 2020, as an advanced screening of episodes 4–8 later aired in the second season. Also shown with a short animation "Kesshouban: Eigakan e Iku". The main staff at Longest home run citizens bank park Production returned for producing the film, with the exception of director Kenichi Suzuki being replaced by director Hirofumi Ogura. It premiered on September 5, 2020.[81]

Cells at Work[edit]

Cells at Work!![edit]

Light novel[edit]

A light novel adaptation of the manga titled as Shōsetsu Hataraku Saibō (小説 はたらく細胞) was published on July 12, 2018, by Kodansha. It is written by Yui Tokiumi and illustrated by Akane Shimizu.[89]

Stage play[edit]

A stage play adaptation titled Tainai White blood cell from cells at work Hataraku Saibō (体内活劇「はたらく細胞」) was announced in the August issue of Kodansha's Monthly Shōnen Sirius magazine.[90] The play was held at Tokyo's Theatre 1010 from November 16 to 25, 2018. The play which was directed by Tsuyoshi Kida, starred Masanari Wada as U-1146 and Kanon Nanaki as AE3803, while Keita Kawajiri wrote the script for the play.[91][92][93] The last performance, which was held on the 25th, was also distributed live.[94]

Mobile app[edit]

A tower-defense game for iOS and Android mobile devices titled Always Cells at Work (いつでも はたらく細胞, Itsudemo Hataraku Saibō) has been announced and is accepting pre-registration for players.[77] The game service shut down at January 31, 2020.[95]


Rebecca Silverman of Anime News Network highlighted the educational aspect of the manga despite flaws in presentation of information, and ultimately found the manga entertaining with likable characters.[96] Sean Gaffney of Manga Bookshelf called it a "very fun shonen action manga", complimenting the manga's ridiculousness and humor.[97] Ian Wolf of Anime UK News gave the British Blu-ray release of the anime a score of 9 out of 10, and described the show as the most bloody on television, because so many of the characters are blood cells and thus means it contains more blood than shows depicting much violence.[98]

The 2016 Kono Manga ga Sugoi! guidebook listed the manga as the seventh top manga for male readers.[99][100]Paul Gravett included the manga in his list of "Top 22 Comics, Graphic Novels & Manga" for October 2016.[101] As of July 2017[update], the manga had over 1.3 million copies in print.[102] The manga had over 1.5 million copies in print, as of January 2018[update].[103]

Dr. Satoru Otsuka, postdoctoral fellow in the molecular neuro-oncology department of Emory University School of Medicine in Atlanta, Georgia, praised the series' depiction of cancer cells during the series' seventh episode.[104] Biology teachers at a high school affiliated with China's Southwest University were so impressed with the accuracy of the series that they assigned it as homework for their students.[105]

See also[edit]



  1. ^Fobian, Peter. "I Asked a Med Student What He Thought About Cells at Work!". Crunchyroll. Retrieved 2019-05-29.
  2. ^"Cells at Work! Vol. 1". ComiXology. Retrieved August 30, 2018.
  3. ^ abcde"Cells at Work! TV Anime Stars Tomoaki Maeno, Kana Hanazawa". Anime News Network. January 25, 2018. Retrieved January 25, 2018.
  4. ^ abcdefghijklSherman, Jennifer (May 17, 2019). "Aniplex of America Reveals Cells at Work! Anime's English Dub Cast, BD Release". Anime News Network. Retrieved May 17, 2019.
  5. ^ abcd"Cells at Work Casts Takahiro Sakurai, Saori Hayami, M.A.O, Nobuhiko Okamoto".
  6. ^ abcdefg"STAFF/CAST". Cells at Work Official USA Website. Aniplex of America. Retrieved May 18, 2019.
  7. ^ abcdeRessler, Karen (May 25, 2018). "Cells at Work Reveals Additional Cast, Opening Theme Song, July 7 Premiere". Anime News Network. Retrieved May 25, 2018.
  8. ^"Cells at Work Anime's Video Reveals More Cast Members". Anime News Network. June 17, 2018. Retrieved June 17, 2018.
  9. ^"はたらく細胞 STAFF/CAST". テレビアニメ「はたらく細胞」 (in Japanese). Retrieved 20 August 2018.
  10. ^Cells at Work! 5. Kodansha Comics. 2017-09-21. pp. 168–170. ISBN .
  11. ^. Natalie (in Japanese). January 26, 2015. Retrieved July 10, 2020.
  12. ^Hodgkins, Crystalyn (December 25, 2020). "Akane Shimizu's Cells at Chs mankato soybean prices Manga Ends in January". Anime News Network. Retrieved January 27, 2021.
  13. ^. Natalie (in Japanese). Natasha, Inc. January 26, 2021. Retrieved January 27, 2021.
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  15. ^"Kodansha Comics Licenses The Prince in His Dark Days, Cells at Work! Manga". Anime News Network. Retrieved 4 June 2017.
  16. ^. Tong Li (in Chinese). Retrieved 4 June 2017.
  17. ^"Fall 2019 New Licensing Announcements from Kodansha Comics + Vertical". Kodansha Comics. 2019-03-11. Retrieved 2019-03-23.
  18. ^"Kodansha Comics Licenses Cells at Work! Spinoffs, That Time I Got Reincarnated (Again!) as a Workaholic Slime Manga". Anime News Network. Retrieved 11 August 2020.
  19. ^Mateo, Alex (October 29, 2021). "Kodansha Comics Licenses The Iceblade Sorcerer Shall Rule the World Manga, Cells at Work Spinoffs". Anime News Network. Retrieved October 29, 2021.
  20. ^"CiNii Books 著者 - 吉田, はるゆき". ci.nii.ac.jp (in Japanese). Retrieved 2018-11-09.
  21. ^"Cells at Work! Manga Gets Spinoff Focusing on Intestinal Bacteria". Anime News Network. Retrieved 4 June 2017.
  22. ^"「はたらく細胞」の腸内版!スピンオフ「はたらく細菌」がなかよしで開幕 - コミックナタリー". コミックナタリー (in Japanese). 2017-04-03. Retrieved 2018-11-09.
  23. ^"Cells at Work: Bacteria! Manga Ends in July". Anime News Network. Retrieved 11 August 2020.
  24. ^"Cells at Work Manga Gets New Spinoff About Cells That Don't Work". Anime News Network. Retrieved 19 January 2018.
  25. ^Sherman, Jennifer (May 18, 2018). "Cells at Work! Gets BLACK Spinoff Manga in June". Anime News Network. Retrieved May 18, 2018.
  26. ^Pineda, Rafael Antonio (January 11, 2019). "Cells at Work Gets New Spinoff Manga on Saturday". Anime News Network. Retrieved January 12, 2019.
  27. ^"Cells at Work! Spinoff Manga About Platelets Launches in May". Anime News Network. April 26, 2019. Retrieved June 24, 2019.
  28. ^Pineda, Rafael Antonio (October 17, 2019). "Cells at Work! Manga Gets New Spinoff Set Inside Baby's Body". Anime News Network. Retrieved July 1, 2020.
  29. ^Hodgkins, Crystalyn (December 21, 2019). "Cells at Work Manga Gets New Hataraku Saibō Lady Spinoff Series". Anime News Network. Retrieved July 1, 2020.
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Источник: https://en.wikipedia.org/wiki/Cells_at_Work!

'Cells At Work!' Season 2 Trailer: Hilarious Anime With Cells As Characters Returns In 2021

Cells At Work! white blood cell from cells at work met with uproarious laughter when the first season of the anime released back in 2018. The anime is based on Akane Shimizu's manga about anthropomorphized cells including Red Blood Cells, White Blood Cells and Platelets working together to keep the human body functioning. Cells are given whole personalities adding to the bizarre yet brilliant concept. And now, it's back for another season. Aniplex just dropped a brand new trailer white blood cell from cells at work the next chapter of Cells At Work! Season 2.

Cells At Work! Season 2 will mark the return of all the characters you love including white blood cell from cells at work weirdly adorable Platelets. While the first instalment revolved around red blood cell AE3803 and white blood cell U-1146, the latest instalment promises to continue their conflicting equation under newer circumstances. At least we know AE3803 is still the loveable rookie we remember. This time around the human bodies housing the cells is threatened by the dengue virus, helicobacter pylori and even acne. The cells are ready to fight to keep the body healthy. While the anime was expected to make a comeback this year, the release date has been pushed to January 2021 as per Aniplex’s announcement. If you really think about it, its only a few months away and quite a timely release in a world hit by the COVID-19 pandemic. It only makes sense to delve deeper into the workings of the human body as its attacked by various diseases.

The original voice actors are reprising their roles from Cells At Work! Season 1. Cells At Work! Season 2 releases somewhere in January, 2021. The franchise also has a film directed by Hirofumi Ogura releasing in September this year.

Cover artwork: Bhavya Poonia/Mashable India

Topics: Entertainment, Trailer, Anime-culture, Anime

Источник: https://in.mashable.com/entertainment/16347/cells-at-work-season-2-trailer-hilarious-anime-with-cells-as-characters-returns-in-2021

Types of WBCs

The different types of white blood cells (leukocytes) include neutrophils, basophils, eosinophils, lymphocytes, monocytes, and macrophages.

Learning Objectives

Distinguish between the two major types of leukocytes (white blood cells): granulocytes and agranulocytes

Key Takeaways

Key Points

  • The two main types of leukocytes are granulocytes and mononuclear leukocytes (agranulocytes).
  • Leukocytes arise from hemopoietic stem cells in the bone marrow. 
  • Leukocytes are involved in pathogen recognition, phagocytosis (ingestion of particles), pathogen destruction, inflammation mediation, and antigen presentation.
  • Granulocytes include neutrophils, basophils, eosinophils, and mast cells. Their granules contain enzymes that damage or digest pathogens and release inflammatory mediators into the bloodstream.
  • Mononuclear leukocytes include lymphocytes, monocytes, macrophages, and dendritic cells. This group is involved in both innate and adaptive immune system function.

Key Terms

  • endocytosed: Engulfed during the process by which the plasma membrane of a cell folds inwards to ingest material.
  • antigen: A substance, usually foreign, that induces an immune response.
  • pathogen: Any organism or substance, especially a microorganism, capable of causing disease. Examples include bacteria, viruses, protozoa, or fungi. Microorganisms are not considered pathogenic until the population has grown large enough to cause disease.

White blood cells (WBCs), or leukocytes, are immune system cells that defend the body against infectious disease and foreign materials. There are several different types of WBCs. They share commonalities but are distinct in form and function. WBCs are produced in the bone marrow by hemopoeitic stem cells, which differentiate into either lymphoid or myeloid progenitor cells. A major distinguishing feature is the presence of granules; white blood cells are often characterized as granulocytes or agranulocytes.


Granulocytes, also known as polymorphonuclear (PMN) leukocytes, are characterized by stained granules within their cytoplasm under a microscope. These granules are membrane-bound enzymes that act primarily in the digestion of endocytosed particles. They may also cause granule dependent cell-mediated apoptosis through the release of perforins, granzymes, and proteases. The nucleus contains multiple lobes (polymorphonuclear) as opposed to a single rounded lobe. Granulocytes contain toll-like receptors that allow them to recognize pathogen-associated molecular patterns (PAMPS). All categories except neutrophils contain IgE receptors that implicate them in allergic responses. There are four types of granulocytes:


Granulocytes: From left to right, a neutrophil, an eosinophil, and a basophil.

  • Neutrophils defend against bacterial or fungal infection and other very small inflammatory processes. They are usually the first responders to microbial infection. Their activity and death in large numbers from degranulation forms purulent necrosis (pus).
  • Eosinophils primarily deal with parasitic infections. They are also the predominant inflammatory cells in allergic reactions. 
  • Basophils are chiefly responsible for short-term inflammatory response (particularly from allergy or irritation) by releasing the chemical histamine, which causes the vasodilation that occurs with inflammation.
  • Mast cells function similarly to basophils in that they often mediate inflammation, white blood cell from cells at work are more common and arise from a different hemopoeitic lineage.

Mononuclear Leukocytes

Mononuclear (MN) leukocytes are characterized by a single round nucleus within the cytoplasm. Some MN leukocytes contain granules while others do not, but the members of this group are sometimes considered agranulocytes by naming convention. MN leukocytes contain lysosomes, small vesicles containing digestive enzymes that break down foreign matter that is endocytosed by the cell during phagocytosis. The cells include:

  • Lymphocytes, which come in three types. B-lymphocytes produce antibodies in the humoral immune response. T-lymphocytes participate in the cell-mediated immune response. NK cells are cytotoxic cells that participate white blood cell from cells at work the innate immune response by killing virally infected and tumor cells and mediating fever and long-lasting inflammation. B and T lymphocytes contain MHC antigen receptors and their activity is antigen-specific. Other leukocytes will attack any pathogen but cannot distinguish between different types of pathogens.
  • Monocytes are large leukocytes that differentiate into macrophages and dendritic cells under varying conditions, while performing similar functions in phagocytosis and antigen presentation (the process by which molecular components are presented to lymphocytes to stimulate an adaptive immune response). Monocytes and their progeny contain toll-like receptors and granules.
  • Macrophages are monocytes that have migrated out of the blood stream and into the internal body tissues. They destroy necrotic cell debris and foreign material including viruses and bacteria, and can present antigens to naive lymphocytes. They typically arrive at the site of inflammation one to three days after the initial neutrophil response to clean up dead neutrophils, cellular debris, and remaining pathogens.
  • Dendritic cells are monocytes that have migrated to cells that are in contact with the external environment, such as the skin, intestines, or respiratory epithelium. Their name comes branched projections called dendrites, which increase their surface area. They phagocytize pathogens and present antigens to naive lymphocytes.

A Macrophage: A macrophage phagocytizes two smaller particles, possibly pathogens

WBC Function

Each type of white blood cell (WBC) has a specific function in defending the body against infections.

Learning Objectives

Describe the functions of leukocytes (white blood cells)

Key Takeaways

Key Points

  • Leukocyte functions often occur in the bloodstream and may represent either the innate or adaptive immune systems.
  • Innate immune system functions are non-specific and include phagocytosis, inflammation, and degranulation.
  • Adaptive immune system functions are antigen -specific and involve antigen presentation as well as  cell -mediated and humoral -mediated activities.
  • Compared to innate immune system functions, adaptive immune system functions take more time to initiate, but work much faster. They have a memory component to prevent reinfection by the same pathogen.

Key Terms

  • macrophage: A white blood cell that phagocytizes necrotic cell debris armstrong bank tahlequah foreign material, including viruses, bacteria, and tattoo ink. It presents foreign antigens on MHC II molecules to lymphocytes. Part of the innate immune system.
  • Inflammation: An innate immune system function in response to a pathogen or injury. Chemical mediators cause the blood vessels to dilate and become more permeable, which draws neutrophils to the area.
  • cytotoxic: Any mechanism that can cause the death of a cell (typically without phagocytosis), such as degranulation or cell mediated apoptosis.

Leukocytes ( white blood cells) provide a number of functions that are primarily related to defending the body from pathogens (foreign invaders). Much leukocyte activity takes place within the bloodstream, but is not restricted to this area. Many leukocytes are able to perform their functions in tissues or organs during normal transport and in response to injury. Leukocyte functions may be classified as either innate or adaptive based on several characteristics.

Innate Bb gun pistol with extended clip System Functions

The innate immune system refers to the body’s ability to prevent pathogen entry and destroy pathogens that do enter the body. Its functions are rapid responses that inhibit a pathogen as soon as it is detected in the body. Innate immune system functions involving leukocytes include:

  • Phagocytosis of pathogens. This process is performed primarily by neutrophils, macrophages, and dendritic cells, but most other leukocytes can do it as well. It involves the binding of an Fc receptor to a tail on a pathogen. The pathogen is engulfed by the leukocyte and destroyed with enzymes and free radicals. 
  • Inflammation. This process is performed primarily by mast cells, eosinophils, basophils, and NK cells. When a pathogen is detected or vascular endothelial cells release stress cytokines from injury such as a cut, leukocytes release a variety of inflammatory cytokines such as histamine or TNF-alpha. These cause vasodilation, increase vascular permeability, and promote neutrophil movement to the inflammation site. 
  • Degranulation. This process is performed by granulocytes like neutrophils. When pathogens are encountered, granule-dependent apoptosis (a mechanism of cytotoxicity) may be induced in the pathogen by releasing perforins, granzymes, and proteases from their granules.

Neutrophils Phagocytizing Bacteria: Here, neutrophils are depicted phagocytizing and completely engulfing bacteria.

Adaptive Immune System Functions

The adaptive immune system is specific to each pathogen on the basis of antigens, molecular components of pathogens used by leukocytes to recognize that specific pathogen. Compared to the innate immune system, adaptive immune functions work much faster and have a memory component that prevents reinfection by the same pathogen. However, more time typically passes before the adpative immune system is functional. Adaptive immune functions of leukocytes include:

  • Antigen presentation. This process is primarily performed by macrophages and dendritic cells. Following phagocytosis, protein components (antigens) of the pathogen are expressed on leukocyte MHC molecules and presented to naive T cells (and B cells) in the lymph nodes. The T cells will then start the adaptive immune response by rapidly proliferating and differentiating.
  • Cell-mediated activities. This process is performed by T cells. Pathogens that bear the T cell’s antigen are destroyed through cytotoxic -induced apoptosis and protease activity.
  • Humoral activities. This process is performed by B cells, which secrete antigen-specific antibodies. The antibodies bind to pathogens to opsonize (mark) them for phagocytes to engulf, neutralize, or start a complement cascade in which proteins form a membrane attack complex to lyse the pathogen.
  • Memory cell activity. Following antigen presentation, memory B and T cells are created. These rapidly produce new T cells or antibodies if the same pathogen is detected in the future. This prevents that pathogen from reinfecting the organism.

WBC Formation

Haematopoiesis refers to the formation of blood cells components. It is necessary for vertebrate function.

Learning Objectives

Describe the formation white blood cell from cells at work leukocytes (white blood cells, or WBCs)

Key Takeaways

Key Points

  • Haematopoietic stem cells are self-renewing and reside in the medulla of the bone ( bone marrow ).
  • All blood cells are divided into two main lineages, produced through lymphoid progenitor cells or myeloid progenitor cells depending on lineage type.
  • Lymphoid progenitor cells differentiate into B and T cells and NK cells.
  • Myeloid progenitor cells differentiate into myelocytes (granulocytes and monocytes) or non-leukocytes such as erythorocytes and megakaryocytes (which grand valley bank colorado platelets).
  • Before birth, most blood cell formation occurs in the liver or spleen, which tend to enlarge when used for hematopoiesis. In adults, most blood production occurs in the bone marrow.

Key Terms

  • myelocyte: A large cell found in bone marrow that becomes a granulocyte or monocyte when mature.
  • differentiation: The gradual changes that occur when a cell or tissue type changes into a different type. Cells generally become more specialized the more they differentiate, and are considered to be terminally differentiated when they cannot differentiate (and often cannot divide) any further.
  • megakaryocyte: A large cell found in bone marrow, responsible for the production of platelets.

Haematopoiesis refers to the formation of blood cellular components, including both white and red blood cells. All cellular blood components are derived from haematopoietic stem cells located within the bone marrow. In a healthy adult, approximately 1011–1012 new blood cells are produced daily to maintain equilibrium levels in peripheral circulation.

Leukocyte Haematopoiesis

Haematopoietic stem cells (HSCs) reside in the bone marrow and have the unique ability to give rise to all mature blood cell types through differentiation into other progenitor cells. HSCs are self-renewing. When they proliferate, at least some daughter cells remain HSCs, so the pool of stem cells does not become depleted over time. The daughters are the myeloid and lymphoid progenitor cells, which cannot self renew but differentiate into various myeloid leukocytes and lymphocytes respectively. This is one of the body’s vital processes.

Leukocyte Lineages

Two different leukocyte lineages and two non-leukocyte lineages arise from the progeny of HSCs. Following this split in differentiation, the subtypes undergo eventual differentiation into terminally-differentiated leukocytes, which typically do not divide independently.

  1. The lymphocyte lineage derives from common lymphoid progenitor cells, which in charles schwab routing number checking account become lymphoblasts before differentiating into T cells, B cells, and NK cells.
  2. Myelocytes are an offshoot of common myeloid progenitor cells, which also differentiate into the erythropoietic and magakaryotic progenitors. This diverse group differentiates into granulocytes and monocytes. Monocytes further differentiate into macrophages or dendritic cells upon reaching certain tissues.
  3. Megakaryocytes (the cells that produce platelets) and erythrocytes (red blood cells) are not formally considered to be leukocytes, but arise from the common myeloid progenitor cells that produce the other cellular components of blood.

Hematopoiesis in Humans: This diagram shows hematopoiesis as it occurs in humans.

Sites of Haematopoesis in Pre- and Postnatal Periods

In developing embryos, blood formation occurs in aggregates of blood cells in the yolk sac called blood islands. However, most of blood supply comes from the mother through the placenta. As development progresses, blood formation occurs primarily in the spleen, liver, and lymph nodes.

When bone marrow develops, it eventually assumes the task of forming most of the blood cells for the entire organism. However, maturation, activation, and some proliferation of lymphoid cells occurs in lymphoid organs (spleen, thymus, and lymph nodes). In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. In adults, it occurs mainly in the pelvis, cranium, vertebrae, and sternum.

In some cases, the liver, thymus, and spleen may resume their haematopoietic function if necessary. This is called extramedullary haematopoiesis. It may cause these organs to hypertrophy and increase in size substantially. During fetal development, the liver functions as the main haematopoetic organ since bones and marrow develop later. Therefore, the liver is enlarged during development relative to its mature proportions.

Источник: https://courses.lumenlearning.com/boundless-ap/chapter/white-blood-cells/

Low white blood cell count

A low white blood cell count usually means your body is not making enough white blood cells. It can increase your risk of getting infections.

What causes a low white blood cell white blood cell from cells at work causes include:

Agranulocytosis and neutropenia are conditions that cause a low white blood cell count.

Treating a low white blood cell count

A blood test can tell you if your white blood cell count is low.

Your treatment will depend on what's causing your condition and will often include antibiotics.

You may also need specific treatment:

  • to boost your white blood cells
  • if you've got an infection

Signs of an infection may include:

  • a high temperature
  • chills and shivering
  • sore throat
  • mouth sores that keep returning
  • toothache
  • skin rashes
  • tiredness
  • flu-like symptoms

Occasionally, infections can lead to a life-threatening condition called sepsis.

Non-urgent advice: See a GP if:

  • you know you're at risk of a low white blood cell count and you get an infection
  • you keep getting infections

Coronavirus (COVID-19) update: how to contact a GP

It's still important to get help from a GP if you need it. To contact your GP surgery:

  • visit their website
  • use the NHS App
  • call them

Find out about using the NHS during COVID-19

Things you can do yourself to avoid infections

If you have a low white blood cell count caused by illness or medicine you should take steps to avoid infections.


  • avoid close contact with people who are sick

  • store and prepare food properly to avoid food poisoning

  • wash your hands with soap and warm water regularly

  • use an electric shaver instead of a razor

  • avoid shared hot tubs


  • do not share food, cups, utensils, toothbrushes or make-up

  • do not eat raw foods, like meat, shellfish and eggs

  • do not change cat litter or handle animal poo

  • do not change nappies

  • do not walk outside barefoot

  • do not swim in ponds and rivers

Page last reviewed: 11 November 2020
Next review due: 11 November 2023

Источник: https://www.nhs.uk/conditions/low-white-blood-cell-count/
white blood cell from cells at work

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